Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5656576 | 0.95 | POLB (0.69) | POLBGAAALOX15MAPK1ALDH1A1 | |
| SCHEMBL31661769 | 0.95 | POLB (0.69) | POLBGAAALOX15MAPK1ALDH1A1 | |
| SCHEMBL3046406 | 0.95 | POLB (0.69) | POLBGAAALOX15MAPK1ALDH1A1 | |
| SCHEMBL7718043 | 0.95 | POLB (0.69) | POLBGAAALOX15MAPK1ALDH1A1 | |
| SCHEMBL7717051 | 0.95 | POLB (0.69) | POLBGAAALOX15MAPK1ALDH1A1 | |
| SCHEMBL13166882 | 0.90 | POLB (0.76) | POLBGAAALOX15MAPK1TDP1 | |
| SCHEMBL5655283 | 0.86 | POLB (0.56) | POLBGAAALOX15MAPK1ALDH1A1 | |
| SCHEMBL31661644 | 0.86 | POLB (0.56) | POLBGAAALOX15MAPK1ALDH1A1 | |
| SCHEMBL13593325 | 0.85 | POLB (0.55) | POLBGAAALOX15MAPK1ALDH1A1 | |
| SCHEMBL13593333 | 0.85 | POLB (0.55) | POLBGAAALOX15MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384278-B1 | REACTING AN AROMATIC AMINE AND AN ALKANOIC ACID OR ESTER IN THE PRESENCE OF A BORON COMPOUND AND OPTIONALLY, A CHELATING AGENT TO PRODUCE AN AROMATIC CARBOXAMIDE SUCH AS 8(5-CHLORO-2 -HYDROXYANILINO)-8-OXOOCTANOIC ACID | EMISPHERE TECHNOLOGIES, INC. | 2002-05-07 | — | — | US | disclosed |