Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 5/20 | 0.56 |
| ▸ | CTSL | P07711 | 5/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.50 |
| ▸ | FABP1 | P07148 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2328576 | 0.92 | CTSV (0.54) | CTSVCTSLSIRT2MAPTHPGD | |
| SCHEMBL7717769 | 0.89 | MAPT (0.58) | FABP1MAPTHPGDSIRT5 | |
| SCHEMBL7721721 | 0.84 | HDAC1 (0.48) | CTSVCTSLFABP1HDAC1MAPT | |
| SCHEMBL2327765 | 0.84 | MEN1 (0.49) | CTSVCTSLSIRT2BACE1HDAC8 | |
| SCHEMBL5579639 | 0.82 | CTSV (0.55) | CTSVCTSLSIRT2BACE1MAPT | |
| SCHEMBL21617259 | 0.81 | CTSV (0.56) | CTSVCTSLSIRT2FABP1FFAR1 | |
| SCHEMBL31504435 | 0.81 | CTSV (0.56) | CTSVCTSLSIRT2FABP1FFAR1 | |
| SCHEMBL2323733 | 0.81 | MAPT (0.55) | MAPTHPGD | |
| SCHEMBL7719700 | 0.81 | SIRT5 (0.48) | MAPTHPGDSIRT5 | |
| SCHEMBL7714467 | 0.80 | MAPT (0.56) | CTSVCTSLFFAR1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |