Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925245 | 0.87 | ADORA3 (0.40) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL1926204 | 0.87 | MEN1 (0.47) | MEN1KMT2APOLBTDP1KDM4E | |
| SCHEMBL7726706 | 0.87 | ADORA3 (0.40) | ADORA3ADORA2AADORA2BADORA1MEN1 | |
| SCHEMBL1924326 | 0.86 | MEN1 (0.47) | MEN1KMT2APOLBGABRG2GABRB3 | |
| SCHEMBL1925329 | 0.86 | MEN1 (0.49) | MEN1KMT2APOLBGABRG2GABRB3 | |
| SCHEMBL27535217 | 0.84 | MEN1 (0.41) | MEN1KMT2APOLBGABRG2GABRB3 | |
| SCHEMBL1925723 | 0.83 | CFTR (0.41) | ADORA3GAAL3MBTL1KDM4EHPGD | |
| SCHEMBL1925105 | 0.83 | MEN1 (0.39) | MEN1KMT2APOLBGABRG2GABRB3 | |
| SCHEMBL1924728 | 0.83 | CRHR1 (0.39) | ADORA3ADORA2AADORA2BADORA1KLK7 | |
| SCHEMBL7720313 | 0.82 | DHODH (0.49) | MEN1KMT2AGAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |