Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720205 | 1.00 | TSHR (0.41) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7723586 | 0.94 | ALDH1A1 (0.43) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7723587 | 0.94 | ALDH1A1 (0.43) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7730105 | 0.92 | P2RX3 (0.41) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7730108 | 0.92 | P2RX3 (0.41) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7723481 | 0.89 | KMT2A (0.47) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7723477 | 0.89 | KMT2A (0.47) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7730137 | 0.85 | TSHR (0.45) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7730133 | 0.85 | TSHR (0.45) | TSHRALDH1A1MAPK1LMNAPOLB | |
| SCHEMBL7724744 | 0.84 | ALDH1A1 (0.43) | TSHRALDH1A1MAPK1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |