Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723670 | 0.89 | MAPT (0.63) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL7724840 | 0.87 | MAPT (0.61) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL7720271 | 0.87 | MAPT (0.64) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL7720270 | 0.85 | MAPT (0.59) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL7724966 | 0.84 | MAPT (0.76) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL7726116 | 0.80 | ADORA2A (0.61) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL6261363 | 0.78 | ALDH1A1 (0.52) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL23297368 | 0.77 | PDE4B (0.71) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL7723462 | 0.77 | PDE4A (0.54) | MAPTADORA2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL7720181 | 0.77 | MAPT (0.53) | MAPTADORA2ASMN1; SMN2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |