SCHEMBL7720271

SCHEMBL7720271

COC(=O)c1cc(-c2ccc(OC)cc2)nn(Cc2ccccc2)c1=O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.64
KMT2A Q03164 2/20 0.54
MEN1 O00255 1/20 0.54
ADORA2A P29274 1/20 0.52
GABRG2 P18507 2/20 0.51
GABRB3 P28472 2/20 0.51
GABRA3 P34903 2/20 0.51
GABRA1 P14867 1/20 0.51
GABRA5 P31644 1/20 0.51
GABRA2 P47869 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.50
HDAC1 Q13547 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
POLB P06746 1/20 0.50
PLA2G2A P14555 3/20 0.49
PDE4A P27815 1/20 0.49
PDE4B Q07343 1/20 0.49
PDE4C Q08493 1/20 0.49
PDE4D Q08499 1/20 0.49
NPC1 O15118 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7723670 0.91 MAPT (0.63) MAPTKMT2AMEN1ADORA2ASMN1; SMN2
SCHEMBL7724966 0.90 MAPT (0.76) MAPTADORA2ASMN1; SMN2TDP1POLB
SCHEMBL7720270 0.89 MAPT (0.59) MAPTKMT2AMEN1ADORA2ASMN1; SMN2
SCHEMBL7720244 0.89 MAPT (0.51) MAPTKMT2AMEN1ADORA2AGABRG2
SCHEMBL7724840 0.89 MAPT (0.61) MAPTKMT2AADORA2ASMN1; SMN2HDAC1
SCHEMBL7723619 0.89 KMT2A (0.54) MAPTKMT2AMEN1GABRG2GABRB3
SCHEMBL7724767 0.87 NPC1 (0.54) MAPTKMT2AMEN1GABRG2GABRB3
SCHEMBL7720258 0.87 MAPT (0.59) MAPTKMT2AMEN1ADORA2ASMN1; SMN2
SCHEMBL7726400 0.86 MAPT (0.68) MAPTKMT2AMEN1SMN1; SMN2HDAC1
SCHEMBL7720344 0.85 PLA2G2A (0.51) MAPTGABRG2GABRB3GABRA3GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6403586-B1 Pyridazine derivatives and drugs containing the same as the active ingredient KOWA CO., LTD. (JP) 2002-06-11 US disclosed
EP-1061077-A1 NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Kowa Co., Ltd. (JP) 2000-12-20 EP disclosed