Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLP1R | P43220 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31729190 | 0.75 | PTGS1 (0.39) | LMNAALDH1A1GLP1RL3MBTL1GAA | |
| SCHEMBL762386 | 0.73 | MAPT (0.58) | ALDH1A1L3MBTL1GAAKDM4EMAPT | |
| SCHEMBL31289927 | 0.72 | MEN1 (0.44) | LMNAALDH1A1CYP1A2GLP1RKDM4E | |
| SCHEMBL29558416 | 0.72 | MEN1 (0.42) | LMNAALDH1A1CYP1A2GLP1RMAPT | |
| SCHEMBL5925649 | 0.72 | MEN1 (0.42) | LMNAALDH1A1CYP1A2GLP1RMAPT | |
| SCHEMBL14725188 | 0.72 | ALDH1A1 (0.46) | LMNAALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL21769050 | 0.72 | LMNA (0.49) | LMNAALDH1A1CYP1A2GLP1RGAA | |
| SCHEMBL21679252 | 0.70 | ALDH1A1 (0.43) | LMNAALDH1A1CYP1A2GLP1RL3MBTL1 | |
| SCHEMBL16398391 | 0.70 | ALDH1A1 (0.43) | LMNAALDH1A1CYP1A2GLP1RL3MBTL1 | |
| SCHEMBL27029927 | 0.70 | KDM5B (0.46) | LMNAALDH1A1CYP1A2GLP1RL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0347146-B1 | FUSED PYRIMIDINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-01 | — | — | EP | disclosed |
| US-5047404-A | Fused pyrimidine derivatives bronchodilator agents, antiallergens | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-09-10 | — | — | US | disclosed |
| EP-0347146-A2 | Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |