Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2327497 | 0.89 | LTB4R (0.48) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL7721735 | 0.88 | SIRT2 (0.45) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL2330597 | 0.87 | LTB4R (0.46) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL2330691 | 0.85 | LTB4R (0.48) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL2328338 | 0.84 | SIRT2 (0.43) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL2326187 | 0.83 | LTB4R (0.46) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL2322879 | 0.81 | SIRT2 (0.43) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL2328696 | 0.80 | ESR1 (0.57) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL7718960 | 0.80 | ESR1 (0.40) | SIRT2SIRT1ESR1ESR2ALDH1A1 | |
| SCHEMBL7721711 | 0.79 | LTB4R (0.41) | SIRT2SIRT1ALDH1A1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |