Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331602 | 0.88 | LTB4R (0.48) | SIRT2SIRT1CYP1A2PDE10ASMN1; SMN2 | |
| SCHEMBL2329165 | 0.88 | LTB4R (0.48) | SIRT2SIRT1CYP1A2PDE10ASMN1; SMN2 | |
| SCHEMBL7721733 | 0.88 | SIRT2 (0.47) | SIRT2SIRT1TP53GAASMN1; SMN2 | |
| SCHEMBL2331912 | 0.87 | ALDH1A1 (0.51) | SIRT2SIRT1CYP1A2PDE10AGAA | |
| SCHEMBL2328763 | 0.87 | LTB4R (0.46) | SIRT2SIRT1CYP1A2PDE10AALDH1A1 | |
| SCHEMBL2330681 | 0.87 | LTB4R (0.46) | SIRT2SIRT1CYP1A2PDE10AALDH1A1 | |
| SCHEMBL2323360 | 0.84 | SIRT2 (0.42) | SIRT2SIRT1CYP1A2PDE10ASMN1; SMN2 | |
| SCHEMBL7721711 | 0.81 | LTB4R (0.41) | SIRT2SIRT1CYP1A2PDE10ATP53 | |
| SCHEMBL7718961 | 0.78 | ALDH1A1 (0.45) | SIRT2SIRT1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL7719686 | 0.78 | TLR8 (0.42) | SIRT2SIRT1TP53LMNADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |