Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 8/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7733554 | 1.00 | HDAC8 (0.40) | HDAC8SRCGPR119USP30MCL1 | |
| SCHEMBL7722035 | 0.92 | HDAC8 (0.39) | HDAC8SRCUSP30FFAR4MMP13 | |
| SCHEMBL7733463 | 0.92 | HDAC8 (0.39) | HDAC8SRCUSP30FFAR4MMP13 | |
| SCHEMBL8150172 | 0.78 | NR1H2 (0.39) | SRC | |
| SCHEMBL7721935 | 0.78 | NR1H2 (0.39) | SRC | |
| SCHEMBL7722122 | 0.78 | NR1H2 (0.39) | SRC | |
| SCHEMBL7727252 | 0.77 | KDM4E (0.46) | HDAC8MCL1 | |
| SCHEMBL7731479 | 0.76 | HDAC8 (0.44) | HDAC8 | |
| SCHEMBL7727102 | 0.76 | USP30 (0.40) | HDAC8GPR119USP30 | |
| SCHEMBL7726796 | 0.76 | USP30 (0.40) | HDAC8GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2000001714-A1 | EFFLUX PUMP INHIBITORS | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-01-13 | — | — | WO | disclosed |