Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7727102 | 1.00 | USP30 (0.40) | USP30MAP2K4FFAR2GPR119NR1H2 | |
| SCHEMBL7726101 | 0.83 | HSD17B10 (0.34) | NR1H2HTRA1UCHL1 | |
| SCHEMBL7727961 | 0.83 | HSD17B10 (0.34) | NR1H2HTRA1UCHL1 | |
| SCHEMBL7728185 | 0.83 | HSD17B10 (0.34) | NR1H2HTRA1UCHL1 | |
| SCHEMBL7733463 | 0.79 | HDAC8 (0.39) | USP30NR1H2RXRANR1H3HDAC8 | |
| SCHEMBL7722035 | 0.79 | HDAC8 (0.39) | USP30NR1H2RXRANR1H3HDAC8 | |
| SCHEMBL7721955 | 0.76 | HDAC8 (0.40) | USP30GPR119HDAC8 | |
| SCHEMBL7733554 | 0.76 | HDAC8 (0.40) | USP30GPR119HDAC8 | |
| SCHEMBL7731725 | 0.75 | HDAC8 (0.44) | HTRA1HDAC8 | |
| SCHEMBL7726393 | 0.74 | PTPN1 (0.39) | NR1H2NR1H3HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |