Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7727754 | 0.92 | POLB (0.44) | HDAC8NPC1MEN1KMT2ACFTR | |
| SCHEMBL7731725 | 0.91 | HDAC8 (0.44) | HDAC8NPC1MEN1KMT2AHTRA1 | |
| SCHEMBL7727252 | 0.90 | KDM4E (0.46) | HDAC8NPC1ALDH1A1SMN1; SMN2GHSR | |
| SCHEMBL7726523 | 0.90 | HDAC8 (0.41) | HDAC8NPC1MEN1KMT2AHTRA1 | |
| SCHEMBL7728192 | 0.88 | POLB (0.47) | HDAC8NPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL7725709 | 0.88 | NPC1 (0.43) | HDAC8NPC1MEN1KMT2AHTRA1 | |
| SCHEMBL7728833 | 0.85 | SIRT2 (0.47) | HDAC8GHSRPOLB | |
| SCHEMBL7722105 | 0.82 | PTPN1 (0.40) | HDAC8NPC1PABPC1KMT2AHTRA1 | |
| SCHEMBL7728565 | 0.81 | MEN1 (0.51) | HDAC8NPC1PABPC1MEN1KMT2A | |
| SCHEMBL7728568 | 0.81 | MEN1 (0.51) | HDAC8NPC1PABPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |