Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887219 | 0.86 | KDM4E (0.39) | KDM4ELMNA | |
| SCHEMBL7732159 | 0.85 | FAP (0.38) | FAPUSP2ALDH1A1CYP3A4MAPT | |
| SCHEMBL7729096 | 0.85 | KDM4E (0.33) | KDM4ELMNA | |
| SCHEMBL7728805 | 0.82 | PLCG1 (0.35) | ALDH1A1MAPTHPGD | |
| SCHEMBL7628021 | 0.74 | KDM4E (0.40) | PTGS1KDM4ELMNA | |
| SCHEMBL7730768 | 0.73 | FAP (0.38) | FAPKDM4ELMNA | |
| SCHEMBL14517164 | 0.72 | FAP (0.40) | FAPPTGS1KDM4ELMNA | |
| SCHEMBL14517157 | 0.72 | FAP (0.40) | FAPPTGS1KDM4ELMNA | |
| SCHEMBL14517169 | 0.71 | FAP (0.39) | FAPUSP2ALDH1A1CYP3A4MAPT | |
| SCHEMBL14517172 | 0.71 | FAP (0.39) | FAPUSP2ALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458780-B1 | IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-10-01 | — | — | US | disclosed |