Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730768 | 0.85 | FAP (0.38) | FAPKDM4ELMNA | |
| SCHEMBL7722648 | 0.85 | FAP (0.36) | FAPKDM4ELMNAPTGS1USP2 | |
| SCHEMBL6893026 | 0.83 | ESR1 (0.40) | KDM4ELMNAPTGS1 | |
| SCHEMBL7732747 | 0.83 | ESR1 (0.36) | KDM4ELMNA | |
| SCHEMBL7732679 | 0.81 | PLCG1 (0.37) | ALDH1A1MAPTHPGD | |
| SCHEMBL6891146 | 0.77 | KDM4E (0.40) | KDM4ELMNAPTGS1 | |
| SCHEMBL6890722 | 0.77 | KDM4E (0.40) | KDM4ELMNAPTGS1 | |
| SCHEMBL7731850 | 0.77 | FAP (0.38) | FAPKDM4ELMNA | |
| SCHEMBL7729672 | 0.77 | FAP (0.38) | FAPKDM4ELMNA | |
| SCHEMBL7722265 | 0.76 | KDM4E (0.34) | KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458780-B1 | IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-10-01 | — | — | US | disclosed |