Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.40 |
| ▸ | PPARA | Q07869 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723276 | 0.84 | PPARG (0.42) | PPARGPPARACA2PPARDFFAR1 | |
| SCHEMBL3731430 | 0.83 | PPARG (0.59) | PPARGPPARAPPARD | |
| SCHEMBL8718200 | 0.81 | PPARG (0.47) | PPARGPPARACA2FFAR1CYP3A4 | |
| SCHEMBL7719097 | 0.78 | PPARG (0.53) | PPARGPPARAPPARD | |
| SCHEMBL9570555 | 0.78 | CA2 (0.48) | PPARGPPARACA2FFAR1PTPN1 | |
| SCHEMBL7719079 | 0.78 | PPARG (0.53) | PPARGPPARAPPARD | |
| SCHEMBL13846806 | 0.77 | CA2 (0.47) | PPARGPPARACA2FFAR1PTPN1 | |
| SCHEMBL7719086 | 0.76 | PPARG (0.51) | PPARGPPARAPPARD | |
| SCHEMBL7722499 | 0.76 | PPARG (0.51) | PPARGPPARAPPARD | |
| SCHEMBL13846795 | 0.76 | SLC2A1 (0.47) | PPARGPPARACA2PPARDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700397-B1 | NEW THIAZOLIDINDIONES AND DRUGS CONTAINING THEM | ROCHE DIAGNOSTICS GMBH (DE) | 2002-09-04 | — | — | EP | claimed |
| US-5599826-A | ANTIDIABETIC AGENT | BOEHRINGER MANNHEIM GMBH (DE) | 1997-02-04 | — | — | US | claimed |
| EP-0700397-B1 | NEW THIAZOLIDINDIONES AND DRUGS CONTAINING THEM | ROCHE DIAGNOSTICS GMBH (DE) | 2002-09-04 | — | — | EP | disclosed |
| US-5599826-A | ANTIDIABETIC AGENT | BOEHRINGER MANNHEIM GMBH (DE) | 1997-02-04 | — | — | US | disclosed |
| EP-0700397-A1 | NEW THIAZOLIDINDIONES AND DRUGS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027995-A1 | NEW THIAZOLIDINDIONES AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1994-12-08 | — | — | WO | disclosed |