SCHEMBL7723378

SCHEMBL7723378

C=CC[C@H]1CC[C@H](c2ccc(C#N)c(F)c2)CC1

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.37
KDM1A O60341 7/20 0.36
EGLN2 Q96KS0 2/20 0.35
AR P10275 1/20 0.34
CHEK1 O14757 2/20 0.34
CYP11B1 P15538 2/20 0.33
CYP11B2 P19099 2/20 0.33
FASN P49327 1/20 0.33
PANK3 Q9H999 1/20 0.33
DRD2 P14416 1/20 0.33
DRD3 P35462 1/20 0.33
USP30 Q70CQ3 1/20 0.32
TRPC3 Q13507 1/20 0.32
TRPC6 Q9Y210 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7723382 1.00 TRPV4 (0.37) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL7739041 0.96 TRPV4 (0.35) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL7739047 0.96 TRPV4 (0.35) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL7739037 0.96 TRPV4 (0.35) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL7739045 0.96 TRPV4 (0.35) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL8973616 0.94 KDM1A (0.33) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL9013826 0.94 KDM1A (0.33) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL8973601 0.94 KDM1A (0.33) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL8973610 0.94 KDM1A (0.33) TRPV4KDM1AEGLN2ARCHEK1
SCHEMBL8973622 0.94 KDM1A (0.33) TRPV4KDM1AEGLN2ARCHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6468606-B1 LOW VISCOSITY, HIGH DIELECTRIC ANISOTROPY, LOW OPTICAL ANISOTROPY, EXCELLENT LOW TEMPERATURE COMPATIBILITY WITH OTHER LIQUID CRYSTALLINE COMPOUNDS; 3,4,5-TRIFLUOROPHENYL-(2-FLUORO-4-(TRANS-4-PROPYLCYCLOHEXYL))BENZOATE CHISSO CORPORATION (JP) 2002-10-22 US disclosed
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
EP-0808825-B1 PHENYL BENZOATE DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS CHISSO CORP (JP) 2001-09-12 EP disclosed
EP-0808886-B1 LIQUID CRYSTAL COMPOSITIONS AND LIQUID CRYSTAL DISPLAY ELEMENTS CHISSO CORP (JP) 2000-08-23 EP disclosed
US-5922243-A LOW VISCOSITY, HIGH DIELECTRIC AND LOW OPTICAL ANISOTROPY, EXCELLENT COMPATIBILITY CHISSO CORPORATION (JP) 1999-07-13 US disclosed
US-5858270-A Difluorooxymethane derivative and liquid crystal composition CHISSO CORPORATION (JP) 1999-01-12 US disclosed
US-5855814-A Liquid crystal compositions and liquid crystal display elements CHISSO CORPORATION (JP) 1999-01-05 US disclosed
EP-0808825-A1 PHENYL BENZOATE DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS CHISSO CORPORATION (JP) 1997-11-26 EP disclosed
EP-0808886-A1 LIQUID CRYSTAL COMPOSITIONS AND LIQUID CRYSTAL DISPLAY ELEMENTS CHISSO CORPORATION (JP) 1997-11-26 EP disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed
EP-0316186-B1 Liquid crystal compositions CHISSO CORP (JP) 1994-08-17 EP disclosed
EP-0318003-B1 A liquid crystal composition for twist nematic mode CHISSO CORP (JP) 1993-10-20 EP disclosed
EP-0232052-B1 NEMATIC LIQUID CRYSTAL COMPOSITION Chisso Corporation (JP) 1993-03-24 EP disclosed
US-5021189-A Supertwisted birefringence display CHISSO CORPORATION (JP) 1991-06-04 US disclosed
US-4923632-A LOW THRESHOLD-VOLTAGE AND TEMPERATURE DEPENDENCY; CYCLOHEXYL-AND FLUORO-SUBSTITUTED BENZENE CHISSO CORPORATION (JP) 1990-05-08 US disclosed
EP-0318003-A2 A liquid crystal composition for twist nematic mode CHISSO CORPORATION (JP) 1989-05-31 EP disclosed
EP-0316186-A2 Liquid crystal compositions Chisso Corporation (JP) 1989-05-17 EP disclosed
US-4776975-A LOW THRESHOLD VOLTAGE AND TEMPERATURE DEPENDENCY CHISSO CORPORATION (JP) 1988-10-11 US disclosed
EP-0232052-A2 Nematic liquid crystal composition Chisso Corporation (JP) 1987-08-12 EP disclosed