Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.69 |
| ▸ | RXRB | P28702 | 11/20 | 0.69 |
| ▸ | RXRG | P48443 | 7/20 | 0.69 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.66 |
| ▸ | RARB | P10826 | 9/20 | 0.64 |
| ▸ | RARG | P13631 | 8/20 | 0.64 |
| ▸ | RARA | P10276 | 5/20 | 0.63 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5680234 | 0.89 | RARB (0.69) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8676373 | 0.82 | RXRA (0.64) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8894039 | 0.82 | RXRA (1.00) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL16516911 | 0.82 | CYP26B1 (0.77) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8013234 | 0.81 | CYP26B1 (0.58) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL29827631 | 0.81 | RARB (0.81) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL846110 | 0.81 | RARB (0.81) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL6880686 | 0.80 | RARB (0.68) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL15555800 | 0.80 | RXRA (0.61) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL17911576 | 0.80 | CYP26B1 (1.00) | RXRARXRBRXRGCYP26B1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391287-B1 | STORAGE STABLE COMPOSITIONS | L'OREAL (FR) | 2002-05-21 | — | — | US | claimed |
| US-5766610-A | USEFUL FOR TREATMENT OF MAMMALIAN SKIN AND HAIR, RHEUMATISM, RESIPIRATORY SYSTEM DISORDER, CARDIOVASCULAR AND VISION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-16 | — | — | US | claimed |
| EP-0679630-B1 | Bicyclic aromatic compounds, pharmaceutical and cosmetic compositions containing them and uses | CIRD GALDERMA (FR) | 1998-05-06 | — | — | EP | claimed |
| WO-1997016422-A1 | SULFIDES, SULFOXIDES AND SULFONES DISUBSTITUTED WITH A TETRAHYDRONAPHTHALENYL, CHROMANYL, THIOCHROMANYL OR TETRAHYDROQUINOLINYL AND SUBSTITUTED PHENYL OR HETEROARYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1997-05-09 | — | — | WO | claimed |
| US-6391287-B1 | STORAGE STABLE COMPOSITIONS | L'OREAL (FR) | 2002-05-21 | — | — | US | disclosed |
| US-6162815-A | RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| US-6156788-A | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-05 | — | — | US | disclosed |
| US-6015569-A | PYRIDINE OR PYRROLE DERIVATIVES OF POLYCYCLIC AROMATICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-01-18 | — | — | US | disclosed |
| US-5766610-A | USEFUL FOR TREATMENT OF MAMMALIAN SKIN AND HAIR, RHEUMATISM, RESIPIRATORY SYSTEM DISORDER, CARDIOVASCULAR AND VISION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-16 | — | — | US | disclosed |
| US-5672710-A | SPECIFIC AGONISTS FOR THE RXR RETINOID RECEPTOR RATHER THAN THE RAR ONE; SIDE EFFECT REDUCTION; SKIN AND NERVOUS SYTEM DISORDERS; ANTICARCINOGENIC AGENTS; VISION DEFECTS | ALLERGAN (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1997016422-A1 | SULFIDES, SULFOXIDES AND SULFONES DISUBSTITUTED WITH A TETRAHYDRONAPHTHALENYL, CHROMANYL, THIOCHROMANYL OR TETRAHYDROQUINOLINYL AND SUBSTITUTED PHENYL OR HETEROARYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1997-05-09 | — | — | WO | disclosed |