Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 14/20 | 0.81 |
| ▸ | RARG | P13631 | 13/20 | 0.81 |
| ▸ | RXRA | P19793 | 12/20 | 0.81 |
| ▸ | RXRB | P28702 | 8/20 | 0.81 |
| ▸ | RXRG | P48443 | 6/20 | 0.81 |
| ▸ | RARA | P10276 | 11/20 | 0.79 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.79 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29827631 | 1.00 | RARB (0.81) | RARBRARGRXRARXRBRXRG | |
| Hydrochloric Acid SCHEMBL9120757 | 0.98 | RARB (0.78) | RARBRARGRXRARXRBRXRG | |
| Hydrazine SCHEMBL9430381 | 0.96 | RARB (0.76) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL10355871 | 0.90 | RXRA (1.00) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL9319026 | 0.90 | RXRA (0.77) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8771781 | 0.90 | RARB (0.67) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL2391376 | 0.89 | RARB (1.00) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL7761329 | 0.89 | RARB (0.80) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL8776544 | 0.89 | RARB (0.65) | RARBRARGRXRARXRBRXRG | |
| SCHEMBL7412191 | 0.87 | RXRA (1.00) | RARBRARGRXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202876-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-06-19 | — | — | US | claimed |
| US-20100029605-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-02-04 | — | — | US | claimed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | claimed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | claimed |
| EP-0337689-A1 | Tetralin esters of phenols or benzoic acids having retinoid like activity | ALLERGAN, INC (US) | 1989-10-18 | — | — | EP | claimed |
| JP-3074353-A | — | — | None | — | — | JP | disclosed |
| CN-115698292-A | Aptamers binding to thiamine analogs and derivatives | 梅里特斯英国第二有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-114773302-A | Benzofuran derivative and medical application thereof | 中国药科大学 | 2022-07-22 | — | — | CN | disclosed |
| US-11364220-B2 | Compounds and methods for inhibiting CPY26 enzymes | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2022-06-21 | — | — | US | disclosed |
| US-20210220326-A1 | Compounds and Methods for Inhibiting CPY26 Enzymes | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2021-07-22 | — | — | US | disclosed |
| CN-112479918-A | Synthetic method of retinoid derivative Am580 | 成都大学 | 2021-03-12 | — | — | CN | disclosed |
| US-10874634-B2 | Compounds and methods for inhibiting CYP26 enzymes | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2020-12-29 | — | — | US | disclosed |
| US-5061705-A | Skin disorders | BASF AKTIENGESELLSCHAFT (DE) | 1991-10-29 | — | — | US | disclosed |
| US-5059621-A | Treatment of dermatologic ailments linked to keratinization disorder | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1991-10-22 | — | — | US | disclosed |
| JP-H0374353-A | NEW AROMATIC CARBOXAMIDE | F HOFFMANN LA ROCHE AG | 1991-03-28 | — | — | JP | disclosed |
| EP-0382077-A2 | Diaryl-substituted heterocyclic compound, its preparation and medicaments and cosmetics made thereof | BASF Aktiengesellschaft (DE) | 1990-08-16 | — | — | EP | disclosed |
| EP-0382078-A1 | Aromatic keto compounds, their preparation and medicinal as well as cosmetic preparations containing them | BASF Aktiengesellschaft (DE) | 1990-08-16 | — | — | EP | disclosed |
| US-4920140-A | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1990-04-24 | — | — | US | disclosed |
| EP-0337689-A1 | Tetralin esters of phenols or benzoic acids having retinoid like activity | ALLERGAN, INC (US) | 1989-10-18 | — | — | EP | disclosed |
| US-4740519-A | Benzo (b) thiophene carboxylate derivatives and pharmaceutical compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1988-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874634-B2 | Compounds and methods for inhibiting CYP26 enzymes | CYP26B1, CYP2A6, CYP26A1 | RARB 14/4885RARG 10/4885RXRA 12/4885 |
| US-20100029605-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | FYN, ABL2, LCK | RARB 1368/4885RARG 2065/4885RXRA 2735/4885 |
| US-11364220-B2 | Compounds and methods for inhibiting CPY26 enzymes | CYP2A6, CYP27A1, CYP26B1 | RARB 34/4885RARG 22/4885RXRA 37/4885 |
| US-20210220326-A1 | Compounds and Methods for Inhibiting CPY26 Enzymes | CYP2A6, CYP27A1, CYP26B1 | RARB 23/4885RARG 13/4885RXRA 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.