Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723577 | 1.00 | MAPT (0.49) | MAPTTSHRALDH1A1MAPK1KDM4E | |
| SCHEMBL7726369 | 0.92 | PLA2G2A (0.48) | MAPTTSHRALDH1A1MAPK1KDM4E | |
| SCHEMBL7726371 | 0.92 | PLA2G2A (0.48) | MAPTTSHRALDH1A1MAPK1KDM4E | |
| SCHEMBL7723676 | 0.91 | MAPT (0.56) | MAPTALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL7723675 | 0.91 | MAPT (0.56) | MAPTALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL7724741 | 0.89 | KDM4E (0.50) | MAPTTSHRALDH1A1KDM4EFNTA | |
| SCHEMBL7724736 | 0.89 | KDM4E (0.50) | MAPTTSHRALDH1A1KDM4EFNTA | |
| SCHEMBL7725042 | 0.88 | CASP1 (0.47) | MAPTTSHRALDH1A1MAPK1KDM4E | |
| SCHEMBL7725047 | 0.88 | CASP1 (0.47) | MAPTTSHRALDH1A1MAPK1KDM4E | |
| SCHEMBL7723562 | 0.86 | MALT1 (0.45) | MAPTTSHRALDH1A1MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |