Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724724 | 0.91 | PKM (0.46) | MEN1KMT2APKMCYP2C9PDE4A | |
| SCHEMBL7725146 | 0.90 | MEN1 (0.41) | MEN1GFERKMT2ASYKPKM | |
| SCHEMBL7726736 | 0.88 | MAPT (0.45) | MEN1KMT2APKMCYP2C9GRM2 | |
| SCHEMBL7720083 | 0.84 | GRIN1 (0.46) | SYKMETCNR2 | |
| SCHEMBL7720154 | 0.84 | JAK2 (0.44) | KMT2A | |
| SCHEMBL1925105 | 0.81 | MEN1 (0.39) | MEN1KMT2APDE4BCNR2 | |
| SCHEMBL7720313 | 0.80 | DHODH (0.49) | MEN1KMT2APKMCYP2C9PDE4A | |
| SCHEMBL1926062 | 0.78 | POLB (0.44) | MEN1KMT2AMETCNR2USP2 | |
| SCHEMBL7726706 | 0.78 | ADORA3 (0.40) | MEN1KMT2ACNR2 | |
| SCHEMBL1925392 | 0.78 | GRM2 (0.39) | MEN1GFERKMT2ASYKGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |