Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10605670 | 0.98 | ALDH1A1 (0.67) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL31377987 | 0.86 | ALDH1A1 (0.70) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL7754100 | 0.86 | ALDH1A1 (0.70) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL11125855 | 0.85 | ALDH1A1 (0.68) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL12386628 | 0.84 | ALDH1A1 (0.71) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL3380213 | 0.83 | ALDH1A1 (0.65) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL9066767 | 0.82 | ALDH1A1 (0.65) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL10715055 | 0.81 | ADRB2 (0.63) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL5132485 | 0.81 | ADRB2 (0.68) | ALDH1A1ADRB2ADRB1LMNAADRB3 | |
| SCHEMBL11813028 | 0.81 | ADRB2 (0.80) | ALDH1A1ADRB2ADRB1LMNAADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355805-B1 | MULTIBINDING COMPOUNDS USEFUL IN TREATMENT AND PREVENTION OF METABOLIC DISORDERS SUCH AS OBESITY AND DIABETES | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| EP-1085894-A1 | BETA 3-ADRENERGIC RECEPTOR AGONISTS | Advanced Medicine, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064053-A1 | β3-ADRENERGIC RECEPTOR AGONISTS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
| US-4388308-A | N6 -[(2-Hydroxypropyl)aryl]adenosines | G.D. SEARLE & CO. (US) | 1983-06-14 | — | — | US | disclosed |