Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | PPARD | Q03181 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633782 | 0.87 | HSD17B10 (0.53) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL5228001 | 0.85 | ALDH1A1 (0.52) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL13633793 | 0.83 | KDM4E (0.54) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL12522017 | 0.82 | KDM4E (0.53) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL4028821 | 0.82 | KDM4E (0.53) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL1051606 | 0.82 | KDM4E (0.53) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL12447266 | 0.78 | ALDH1A1 (0.53) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL5103108 | 0.78 | KDM4E (0.50) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL5800641 | 0.78 | KDM4E (0.50) | KDM4EMEN1POLBKMT2ANPSR1 | |
| SCHEMBL12442798 | 0.78 | PPARA (0.64) | KDM4EALDH1A1HPGDMAPTPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700397-B1 | NEW THIAZOLIDINDIONES AND DRUGS CONTAINING THEM | ROCHE DIAGNOSTICS GMBH (DE) | 2002-09-04 | — | — | EP | disclosed |
| US-5599826-A | ANTIDIABETIC AGENT | BOEHRINGER MANNHEIM GMBH (DE) | 1997-02-04 | — | — | US | disclosed |
| EP-0700397-A1 | NEW THIAZOLIDINDIONES AND DRUGS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027995-A1 | NEW THIAZOLIDINDIONES AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1994-12-08 | — | — | WO | disclosed |