Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31357779 | 0.83 | NR3C2 (0.46) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL9779480 | 0.82 | TSHR (0.47) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL30872976 | 0.80 | CA12 (0.50) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL7920273 | 0.77 | TSHR (0.41) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL17333643 | 0.77 | ESR1 (0.56) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL4204976 | 0.76 | PKM (0.47) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL13762630 | 0.74 | CA12 (0.50) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL7645581 | 0.72 | PSIP1 (0.41) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL28347318 | 0.72 | PSIP1 (0.41) | TSHRALDH1A1GLAESR1MAPK1 | |
| SCHEMBL17333692 | 0.72 | ESR1 (0.51) | TSHRALDH1A1GLAESR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |