Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | IL1RN | P18510 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 3/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14191076 | 0.77 | KEAP1 (0.50) | KEAP1NR3C2CA1CA2IL1RN | |
| SCHEMBL4099446 | 0.75 | KEAP1 (0.58) | KEAP1CA1CA2PGRIL1RN | |
| SCHEMBL24980893 | 0.74 | KEAP1 (0.47) | KEAP1NR3C2CA1CA2IL1RN | |
| SCHEMBL28215832 | 0.72 | KEAP1 (0.46) | KEAP1NR3C2CA1CA2IL1RN | |
| SCHEMBL18722578 | 0.72 | KEAP1 (0.54) | KEAP1NR3C2CA1CA2PGR | |
| SCHEMBL18638754 | 0.72 | KEAP1 (0.54) | KEAP1NR3C2CA1CA2PGR | |
| SCHEMBL473378 | 0.72 | TDP1 (0.52) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL21239626 | 0.71 | KEAP1 (0.48) | KEAP1NR3C2CA1CA2IL1RN | |
| Hydrochloric Acid SCHEMBL473354 | 0.71 | TDP1 (0.50) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL10532103 | 0.71 | KEAP1 (0.52) | KEAP1NR3C2CA1CA2IL1RN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |