Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | IL1RN | P18510 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14191076 | 0.81 | KEAP1 (0.50) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL4099446 | 0.77 | KEAP1 (0.58) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL21283390 | 0.75 | KEAP1 (0.47) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL7724502 | 0.74 | KEAP1 (0.46) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL28215832 | 0.74 | KEAP1 (0.46) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL18722578 | 0.73 | KEAP1 (0.54) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL18638754 | 0.73 | KEAP1 (0.54) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL21239626 | 0.73 | KEAP1 (0.48) | KEAP1CA1CA2IL1RNERAP1 | |
| SCHEMBL17323164 | 0.72 | PSIP1 (0.48) | CA1CA2CA12CA9LMNA | |
| SCHEMBL6332337 | 0.71 | MMP2 (0.44) | KEAP1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230032020-A1 | SMALL-MOLECULE COVALENT INHIBITION OF RAL GTPASES | NATIONAL INSTITUTES OF HEALTH | 2023-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230032020-A1 | SMALL-MOLECULE COVALENT INHIBITION OF RAL GTPASES | RALA, KRAS, HRAS | KEAP1 1432/4885CA1 3899/4885CA2 1627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.