Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL430682 | 0.76 | METAP1 (0.42) | PDE4BCHEK2ROS1MARK3LTK | |
| SCHEMBL427867 | 0.76 | ALDH1A1 (0.44) | BRD4TDP1L3MBTL1TDP2PARP1 | |
| SCHEMBL3361714 | 0.75 | TDP1 (0.47) | TDP1L3MBTL1PARP1PARP10 | |
| SCHEMBL12987982 | 0.75 | TDP1 (0.47) | TDP1L3MBTL1PARP1PARP10 | |
| SCHEMBL3361711 | 0.75 | TDP1 (0.47) | TDP1L3MBTL1PARP1PARP10 | |
| SCHEMBL450079 | 0.74 | BACE1 (0.44) | BACE1 | |
| SCHEMBL450080 | 0.74 | BACE1 (0.44) | BACE1 | |
| SCHEMBL1794485 | 0.74 | PNMT (0.40) | BRD4PGRTDP2CMA1AHR | |
| SCHEMBL428969 | 0.73 | IDO1 (0.35) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL446630 | 0.72 | SMN1; SMN2 (0.36) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |