Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | UBE2N | P61088 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7725234 | 0.87 | HTT (0.46) | MAPTKDM4EHPGDHTTLMNA | |
| SCHEMBL11230793 | 0.87 | CASP1 (0.53) | MAPTTDP1POLBALDH1A1KDM4E | |
| SCHEMBL7724769 | 0.86 | MAPT (0.55) | MAPTTDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL7723506 | 0.86 | MAPT (0.55) | MAPTTDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL7723543 | 0.85 | MAPT (0.57) | MAPTTDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL7720367 | 0.84 | MAPT (0.51) | MAPTTDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL7720154 | 0.83 | JAK2 (0.44) | MAPTPOLBRECQLALDH1A1KDM4E | |
| SCHEMBL7724779 | 0.83 | MAPT (0.53) | MAPTTDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL7724966 | 0.83 | MAPT (0.76) | MAPTTDP1L3MBTL1POLBAPEX1 | |
| SCHEMBL7720119 | 0.83 | MAPT (0.53) | MAPTTDP1L3MBTL1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |