Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | UBE2N | P61088 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723615 | 0.87 | SMN1; SMN2 (0.44) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL7723582 | 0.84 | ALDH1A1 (0.44) | MAPTALDH1A1KDM4EHTTPOLB | |
| SCHEMBL7724769 | 0.84 | MAPT (0.55) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL7723506 | 0.84 | MAPT (0.55) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL7730097 | 0.84 | LMNA (0.48) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL7723676 | 0.83 | MAPT (0.56) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL7723675 | 0.83 | MAPT (0.56) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL7723543 | 0.83 | MAPT (0.57) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL7724761 | 0.83 | MAPT (0.54) | MAPTALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL7723577 | 0.82 | MAPT (0.49) | MAPTALDH1A1KDM4EHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |