Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7724774 | 1.00 | CASP1 (0.44) | CASP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL7725042 | 0.90 | CASP1 (0.47) | CASP1MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL7725047 | 0.90 | CASP1 (0.47) | CASP1MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL7723497 | 0.88 | ALDH1A1 (0.45) | MAPTALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL7723499 | 0.88 | ALDH1A1 (0.45) | MAPTALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL7723675 | 0.87 | MAPT (0.56) | CASP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL7723676 | 0.87 | MAPT (0.56) | CASP1MAPTALDH1A1LMNAHTT | |
| SCHEMBL7724741 | 0.83 | KDM4E (0.50) | MAPTALDH1A1TSHRASIC1KDM4E | |
| SCHEMBL7724736 | 0.83 | KDM4E (0.50) | MAPTALDH1A1TSHRASIC1KDM4E | |
| SCHEMBL7724840 | 0.82 | MAPT (0.61) | CASP1MAPTALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |