Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734105 | 0.89 | TOP2A (0.48) | TOP2AMAPTPOLBNPC1RAB9A | |
| SCHEMBL1271524 | 0.80 | SMN1; SMN2 (0.49) | TOP2AMAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL7721972 | 0.77 | TOP2A (0.55) | TOP2AMAPTPOLBNPC1RAB9A | |
| SCHEMBL4307487 | 0.76 | TOP2A (0.54) | TOP2AMAPTPOLBNPC1RAB9A | |
| SCHEMBL9178689 | 0.76 | TOP2A (0.54) | TOP2AMAPTPOLBNPC1RAB9A | |
| SCHEMBL7735172 | 0.75 | SMN1; SMN2 (0.59) | MAPTPOLBNPC1RAB9AALDH1A1 | |
| SCHEMBL7440762 | 0.75 | TOP2A (0.55) | TOP2AMAPTPOLBNPC1RAB9A | |
| SCHEMBL27379841 | 0.73 | TOP2A (0.51) | TOP2AMAPTNPC1RAB9AKDM4E | |
| SCHEMBL4303871 | 0.72 | TOP2A (0.50) | TOP2AMAPTPOLBNPC1RAB9A | |
| SCHEMBL12900291 | 0.72 | TOP2A (0.47) | TOP2AMAPTNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372770-B1 | TREATING A MAMMAL SUFFERING FROM A DISEASE STATE SELECTED FROM THE GROUP CONSISTING OF ASTHMA, ALLERGIES, INFLAMMATION, DEPRESSION, DEMENTIA, ATOPIC DISEASES, RHINITIS AND DISEASE STATES ASSOCIATED WITH ABNORMALLY HIGH PHYSIOLOGICAL LEVELS OF | EURO-CELTIQUE, S.A. | 2002-04-16 | — | — | US | disclosed |