Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7729357 | 0.77 | NPC1 (0.59) | ATAD2SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL12369671 | 0.76 | LRRK2 (0.46) | MAP4K4MKNK1MKNK2ATAD2NOS3 | |
| SCHEMBL15471366 | 0.76 | S1PR1 (0.41) | MAP4K4MKNK1MKNK2ATAD2NOS3 | |
| SCHEMBL12395272 | 0.73 | MAPT (0.44) | MAP4K4NOS3NOS1NOS2SMN1; SMN2 | |
| SCHEMBL10062975 | 0.72 | MAP4K4 (0.59) | MAP4K4MKNK1MKNK2NOS3NOS1 | |
| SCHEMBL10365056 | 0.71 | ACHE (0.31) | SMN1; SMN2NPC1RAB9AACHE | |
| SCHEMBL31415090 | 0.71 | NPC1 (0.37) | ATAD2SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL29188883 | 0.71 | NPC1 (0.37) | ATAD2SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL876753 | 0.70 | NOTUM (0.51) | MAP4K4MKNK1MKNK2NOS3NOS1 | |
| SCHEMBL30968134 | 0.70 | MAP4K4 (0.57) | MAP4K4MKNK1MKNK2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420367-B1 | RAS GENE | SHIONOGO & CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1097933-A1 | PYRIMIDINE DERIVATIVES EXHIBITING ANTITUMOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2001-05-09 | — | — | EP | disclosed |