Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | BAD | Q92934 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19697741 | 0.76 | RXRA (0.47) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL3365242 | 0.73 | RXRA (0.50) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL16559080 | 0.73 | RXRA (0.47) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL9092770 | 0.72 | RXRA (0.53) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL26107653 | 0.70 | TRPA1 (0.39) | ALDH1A1LMNAMEN1KMT2ATSHR | |
| SCHEMBL16577649 | 0.70 | RXRA (0.45) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL24114484 | 0.70 | RXRA (0.43) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL8887944 | 0.70 | RXRA (0.45) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL15465888 | 0.70 | RXRA (0.50) | RXRARXRBRXRGALDH1A1BCL2L1 | |
| SCHEMBL28747345 | 0.70 | ESR1 (0.44) | ALDH1A1LMNAMEN1KMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372920-B1 | ALKYLATING 2-AMINOTETRALIN IN PRESENCE OF BASE SELECTED FROM ALKALI METAL CARBONATES AND BICARBONATES, WHEREIN AMOUNT OF BASE IS LESS THAN ABOUT 1.9-FOLD MOLAR EXCESS WITH RESPECT TO AMOUNT OF 2-AMINOTETRALIN | ADERIS PHARMACEUTICALS, INC. | 2002-04-16 | — | — | US | disclosed |