Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.61 |
| ▸ | MMP2 | P08253 | 3/20 | 0.60 |
| ▸ | MMP9 | P14780 | 3/20 | 0.60 |
| ▸ | MMP8 | P22894 | 3/20 | 0.60 |
| ▸ | MMP13 | P45452 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.58 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.57 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | ADK | P55263 | 1/20 | 0.56 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.56 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16088593 | 0.85 | ALDH1A1 (0.56) | KDM4EALDH1A1TRPV1MTORADK | |
| SCHEMBL3885090 | 0.84 | TRPV1 (0.74) | KDM4EALDH1A1TRPV1 | |
| SCHEMBL4708290 | 0.83 | KDM4E (0.63) | KDM4EALDH1A1TRPV1MTORADK | |
| SCHEMBL15652573 | 0.82 | ADRB2 (0.49) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL16127893 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1TRPV1MTORADK | |
| SCHEMBL6005085 | 0.80 | ALDH1A1 (0.73) | KDM4EALDH1A1MTORADKNISCH | |
| SCHEMBL1063177 | 0.79 | HDAC1 (0.61) | KDM4EALDH1A1 | |
| SCHEMBL18085798 | 0.78 | PTPN1 (1.00) | PTPN1KDM4ETRPV1POLBSTAT3 | |
| SCHEMBL15653051 | 0.77 | AURKA (0.52) | KDM4EALDH1A1TRPV1HPSEPOLB | |
| SCHEMBL1662948 | 0.76 | MAPT (0.48) | MMP2MMP9MMP8MMP13KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403302-B1 | DOUBLE HELICAL NUCLEIC ACID COMPRISING COMPLEMENTARY STRANDS AND OLIGONUCLEOTIDE BOUND TO TARGET SEQUENCE WITHIN; GENETIC ENGINEERING; DIAGNOSING GENE DISORDERS; ANTIPARALLEL ORIENTATION; NON-DENATURING | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2002-06-11 | — | — | US | disclosed |