Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 10/20 | 0.57 |
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.54 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.52 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250135 | 0.86 | IMPDH2 (0.73) | IMPDH2IMPDH1SETD7 | |
| SCHEMBL7208989 | 0.82 | IMPDH2 (0.73) | IMPDH2AAK1IMPDH1ROCK2ROCK1 | |
| SCHEMBL7080348 | 0.74 | IMPDH2 (0.53) | IMPDH2AAK1IMPDH1ROCK2ROCK1 | |
| SCHEMBL1474411 | 0.74 | IMPDH2 (1.00) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL3863160 | 0.73 | IMPDH2 (0.60) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL30292051 | 0.73 | IMPDH2 (0.60) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL12749604 | 0.73 | IMPDH2 (0.80) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL5010235 | 0.73 | IMPDH2 (0.63) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL6170235 | 0.73 | IMPDH2 (0.81) | IMPDH2AAK1IMPDH1ROCK2ROCK1 | |
| SCHEMBL7724586 | 0.72 | AAK1 (0.65) | IMPDH2AAK1IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399773-B1 | AUTOIMMUNE DISEASE; TRANSPLANTING ORGANS | BRISTOL-MYERS SQUIBB CO. | 2002-06-04 | — | — | US | disclosed |