SCHEMBL7729256

SCHEMBL7729256

O=C1c2ccccc2C(=O)N1c1ccc(Cl)cc1F

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
CYP3A4 P08684 1/20 0.53
NFKB1 P19838 1/20 0.53
PMP22 Q01453 1/20 0.53
ESR1 P03372 1/20 0.53
ESR2 Q92731 1/20 0.53
GAA P10253 1/20 0.44
CASP6 P55212 1/20 0.44
GRM1 Q13255 2/20 0.44
GRM4 Q14833 1/20 0.44
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
CA7 P43166 1/20 0.43
POLB P06746 1/20 0.42
ALDH1A1 P00352 1/20 0.42
ALDH2 P05091 1/20 0.42
ALDH3A1 P30838 1/20 0.42
SCN2A Q99250 1/20 0.42
S100A4 P26447 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30273429 1.00 MEN1 (0.53) MEN1KMT2ACYP3A4NFKB1PMP22
SCHEMBL11826010 0.89 MEN1 (0.46) MEN1KMT2ACYP3A4NFKB1PMP22
SCHEMBL7733754 0.85 ESR1 (0.56) MEN1KMT2ACYP3A4NFKB1PMP22
SCHEMBL10626656 0.82 ESR1 (0.56) MEN1KMT2ACYP3A4NFKB1PMP22
SCHEMBL10421175 0.81 CA1 (0.44) KMT2AESR1ESR2GRM1CA1
SCHEMBL19707985 0.80 CA1 (0.43) MEN1KMT2AESR1ESR2CA1
SCHEMBL5924351 0.79 CYP3A4 (0.66) MEN1KMT2ACYP3A4NFKB1PMP22
SCHEMBL5391799 0.79 CYP3A4 (0.61) MEN1KMT2ACYP3A4NFKB1PMP22
SCHEMBL6678239 0.79 ESR1 (0.53) MEN1KMT2ACYP3A4NFKB1PMP22
SCHEMBL30273450 0.79 ESR1 (0.53) MEN1KMT2ACYP3A4NFKB1PMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115701423-A Preparation method of trifluoroethyl sulfide (sulfoxide) substituted benzene compound and intermediate thereof 沈阳化工大学 2023-02-10 CN disclosed
US-6365753-B1 EXCELLENT PREFERENTIAL EFFECTS ON WEEDS; GRASSES; NONPHYTOTOXIC TO CROPS E.G. WHEAT; BARLEY; CORN MITSUBISHI CHEMICAL CORPORATION (JP) 2002-04-02 US disclosed
EP-1097923-A1 PHTHALIMIDES AND HERBICIDE CONTAINING THE SAME AS ACTIVE COMPONENT MITSUBISHI CHEMICAL CORPORATION (JP) 2001-05-09 EP disclosed