SCHEMBL7733754

SCHEMBL7733754

O=C1c2ccc(F)cc2C(=O)N1c1ccc(Cl)cc1F

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.56
ESR2 Q92731 2/20 0.56
AR P10275 3/20 0.49
GRM1 Q13255 6/20 0.43
GRM4 Q14833 5/20 0.43
MEN1 O00255 1/20 0.42
GAA P10253 1/20 0.42
CASP6 P55212 1/20 0.42
KMT2A Q03164 1/20 0.42
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA7 P43166 1/20 0.40
MPI P34949 1/20 0.39
PHOSPHO1 Q8TCT1 1/20 0.39
PARK7 Q99497 1/20 0.39
CYP3A4 P08684 1/20 0.39
NFKB1 P19838 1/20 0.39
PMP22 Q01453 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30273429 0.85 MEN1 (0.53) ESR1ESR2GRM1GRM4MEN1
SCHEMBL7729256 0.85 MEN1 (0.53) ESR1ESR2GRM1GRM4MEN1
SCHEMBL17326671 0.79 MEN1 (0.62) ESR1ESR2ARMEN1KMT2A
SCHEMBL10626656 0.78 ESR1 (0.56) ESR1ESR2GRM1GRM4MEN1
SCHEMBL30367593 0.78 ESR1 (0.85) ESR1ESR2GRM1GRM4
SCHEMBL20423488 0.78 ESR1 (0.85) ESR1ESR2GRM1GRM4
SCHEMBL7731694 0.78 ESR1 (0.46) ESR1ESR2ARGRM1GRM4
SCHEMBL10421175 0.77 CA1 (0.44) ESR1ESR2GRM1KMT2ACA1
SCHEMBL7564128 0.76 AR (0.51) ESR1ESR2ARMEN1GAA
SCHEMBL19707985 0.76 CA1 (0.43) ESR1ESR2MEN1KMT2ACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6365753-B1 EXCELLENT PREFERENTIAL EFFECTS ON WEEDS; GRASSES; NONPHYTOTOXIC TO CROPS E.G. WHEAT; BARLEY; CORN MITSUBISHI CHEMICAL CORPORATION (JP) 2002-04-02 US disclosed
EP-1097923-A1 PHTHALIMIDES AND HERBICIDE CONTAINING THE SAME AS ACTIVE COMPONENT MITSUBISHI CHEMICAL CORPORATION (JP) 2001-05-09 EP disclosed