SCHEMBL7729413

Cc1nc(C(=O)CO[Si](C)(C)C(C)(C)C)c2sc(C3=C(C(=O)OCc4ccc([N+](=O)[O-])cc4)N4C(=O)[C@H]([C@@H](C)O)[C@H]4[C@H]3C)cn12

nearest known ligand 0.33

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	PLCG1	P19174	1/20	0.33

▸	LMNA	P02545	1/20	0.32

▸	ELANE	P08246	2/20	0.31

▸	POLB	P06746	1/20	0.31

▸	SMN1; SMN2	Q16637	1/20	0.31

▸	HTR2A	P28223	1/20	0.30

▸	FAP	Q12884	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7728620	0.91	PLCG1 (0.36)	PLCG1ELANEPOLBSMN1; SMN2HTR2A
SCHEMBL7722268	0.90	PLCG1 (0.36)	PLCG1LMNAELANEPOLBSMN1; SMN2
SCHEMBL7722562	0.89	PLCG1 (0.32)	PLCG1ELANEHTR2AFAP
SCHEMBL7734511	0.89	PLCG1 (0.36)	PLCG1LMNAELANEPOLBSMN1; SMN2
SCHEMBL7729305	0.88	PLCG1 (0.35)	PLCG1LMNAELANEPOLBSMN1; SMN2
SCHEMBL7722449	0.85	PLCG1 (0.38)	PLCG1ELANEPOLBSMN1; SMN2HTR2A
SCHEMBL7729063	0.85	PLCG1 (0.38)	PLCG1ELANEPOLBSMN1; SMN2HTR2A
SCHEMBL6886034	0.85	FAP (0.30)	FAP
SCHEMBL7722528	0.84	L3MBTL1 (0.38)	PLCG1ELANEPOLBSMN1; SMN2HTR2A
SCHEMBL7722513	0.84	PLCG1 (0.36)	PLCG1ELANEPOLBSMN1; SMN2HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6458780-B1	IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND	MEIJI SEIKA KAISHA, LTD. (JP)	2002-10-01	—	—	US	disclosed