Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8730213 | 0.79 | TAAR1 (0.58) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL20411848 | 0.77 | TAAR1 (0.44) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL5667854 | 0.76 | TAAR1 (0.48) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL284909 | 0.76 | TAAR1 (0.48) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL172905 | 0.75 | CYP2C19 (0.46) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL10668141 | 0.75 | CYP2C19 (0.46) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL460018 | 0.74 | TAAR1 (0.65) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL7642588 | 0.74 | CYP2C19 (0.46) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL4249887 | 0.74 | TAAR1 (0.46) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 | |
| SCHEMBL17907133 | 0.74 | TAAR1 (0.46) | TAAR1MAPK1CYP2C19HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1202084-C | Fused benzene heterocycle derivatives and utilization thereof | TORAY INDUSTRIES (JP) | 2005-05-18 | — | — | CN | disclosed |
| US-6407096-B1 | 1,4-BENZOTHIAZINE AND 1,4-BENZOXAZINE DERIVATIVES; HYPOTENSIVE, ANTIISCHEMIC, ANTIALLERGEN, ANTIASTHMATIC AND ANTICOAGULANT AGENTS; CARDIOVASCULAR DISORDERS | TORAY INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| CN-1287553-A | Fused benzene heterocycle derivatives and utilization thereof | TORAY INDUSTRIES (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1028113-A1 | FUSED BENZENE HETEROCYCLE DERIVATIVES AND UTILIZATION THEREOF | TORAY INDUSTRIES, INC. (JP) | 2000-08-16 | — | — | EP | disclosed |
| EP-0009640-B1 | POLYPHOSPHAZENE POLYMERS CONTAINING CYCLIC SUBSTITUENTS FROM 1,2- OR 1,3-DIFUNCTIONAL COMPOUNDS AND PROCESS FOR PREPARING SAME | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1983-08-17 | — | — | EP | disclosed |
| US-4219637-A | Polyphosphazene polymers containing cyclic substituents from 1,2- or 1,3-difunctional compounds | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1980-08-26 | — | — | US | disclosed |
| EP-0009640-A1 | Polyphosphazene polymers containing cyclic substituents from 1,2- or 1,3-difunctional compounds and process for preparing same | THE FIRESTONE TIRE & RUBBER COMPANY (US) | 1980-04-16 | — | — | EP | disclosed |