Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7719886 | 0.89 | MAPT (0.70) | MAPTMEN1GAAKMT2AALPL | |
| SCHEMBL1926175 | 0.85 | MAPT (0.55) | MAPTMEN1GAAKMT2AALPL | |
| SCHEMBL22728840 | 0.83 | MAPT (0.68) | MAPTMEN1GAAKMT2AALPL | |
| SCHEMBL7724864 | 0.81 | MAPT (0.68) | MAPTALPLRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1924210 | 0.79 | ALPL (0.68) | MAPTMEN1GAAKMT2AALPL | |
| SCHEMBL1925099 | 0.79 | GSK3B (0.50) | MAPTGAAALPLRAB9ASMN1; SMN2 | |
| SCHEMBL1924655 | 0.78 | GAA (0.63) | MAPTMEN1GAAKMT2AALPL | |
| SCHEMBL1925116 | 0.78 | GAA (0.67) | MAPTGAAALPLRAB9ASMN1; SMN2 | |
| SCHEMBL5650772 | 0.78 | MAPT (0.48) | MAPTGAAALPLRAB9ASMN1; SMN2 | |
| SCHEMBL11149356 | 0.77 | MAPT (0.60) | MAPTMEN1GAAKMT2AALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |