Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | GGT1 | P19440 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256745 | 0.71 | SRC (0.44) | KDM4ENPC1HTTRAB9APLK1 | |
| SCHEMBL11411843 | 0.69 | LMNA (0.61) | KDM4EHTTLMNAALDH1A1MAPT | |
| SCHEMBL6254976 | 0.68 | KDM4E (0.41) | KDM4ENPC1HTTRAB9ALMNA | |
| SCHEMBL6260118 | 0.67 | PTGIR (0.48) | KDM4ENPC1HTTRAB9AALDH1A1 | |
| SCHEMBL6256619 | 0.67 | CYP1A2 (0.48) | KDM4EHTTLMNAALDH1A1MAPT | |
| SCHEMBL9911886 | 0.64 | PIK3CD (0.42) | KDM4ENPC1HTTRAB9APLK1 | |
| SCHEMBL7723469 | 0.64 | JAK2 (0.52) | KDM4ENPC1HTTRAB9APLK1 | |
| SCHEMBL23484773 | 0.64 | PLK1 (0.89) | KDM4ENPC1HTTRAB9APLK1 | |
| SCHEMBL14722006 | 0.64 | PLK1 (0.89) | KDM4ENPC1HTTRAB9APLK1 | |
| SCHEMBL17290647 | 0.62 | MEN1 (0.47) | KDM4ENPC1RAB9ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |