SCHEMBL7730645

SCHEMBL7730645

Cc1ccc(OC(F)(F)c2ccc(C(F)(F)Oc3ccc(C)cc3)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 4/20 0.42
TSHR P16473 2/20 0.42
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 2/20 0.41
CA5A P35218 1/20 0.41
KIF11 P52732 2/20 0.38
HTR2A P28223 1/20 0.38
SLC6A4 P31645 1/20 0.38
KCNH2 Q12809 1/20 0.38
BCHE P06276 1/20 0.38
MLYCD O95822 1/20 0.37
GPR3 P46089 1/20 0.37
CYP3A4 P08684 1/20 0.37
TEAD4 Q15561 1/20 0.37
TDP1 Q9NUW8 2/20 0.36
ALDH1A1 P00352 1/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
MEN1 O00255 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12829128 1.00 ACHE (0.42) ACHETSHRCA1CA2CA9
SCHEMBL13104749 1.00 ACHE (0.42) ACHETSHRCA1CA2CA9
SCHEMBL10018707 0.94 ACHE (0.38) ACHETSHRCA1CA2CA9
SCHEMBL7729109 0.94 ACHE (0.45) ACHETSHRKIF11KCNH2BCHE
SCHEMBL12152581 0.94 ACHE (0.38) ACHETSHRCA1CA2CA9
SCHEMBL25120146 0.92 ACHE (0.58) ACHECA1CA2CA9KIF11
SCHEMBL13038185 0.92 ACHE (0.58) ACHECA1CA2CA9KIF11
SCHEMBL13808361 0.89 KCNH2 (0.39) ACHETSHRCA1CA2CA9
SCHEMBL13808375 0.89 KCNH2 (0.39) ACHETSHRCA1CA2CA9
SCHEMBL13808348 0.89 GRM5 (0.39) ACHETSHRCA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed