Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 3/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6704988 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HSD11B1PTGS2KMT2AGRM6 | |
| SCHEMBL6704991 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HSD11B1PTGS2KMT2AGRM6 | |
| SCHEMBL6751381 | 1.00 | ALDH1A1 (0.41) | ALDH1A1HSD11B1PTGS2KMT2AGRM6 | |
| SCHEMBL27696935 | 0.81 | KDM1A (0.39) | ALDH1A1HSD11B1KMT2A | |
| SCHEMBL6695849 | 0.79 | HSD11B1 (0.45) | HSD11B1KMT2AGRM6GRM2HTR2A | |
| SCHEMBL10389165 | 0.77 | HSD11B1 (0.44) | ALDH1A1HSD11B1PTGS2 | |
| SCHEMBL14272790 | 0.73 | HSD11B1 (0.53) | ALDH1A1HSD11B1PTGS2KMT2AAKR1C1 | |
| SCHEMBL1222859 | 0.71 | HSD11B1 (0.51) | ALDH1A1HSD11B1PTGS2 | |
| SCHEMBL19726828 | 0.69 | HSD11B1 (0.58) | ALDH1A1HSD11B1KMT2AHTR2A | |
| SCHEMBL7737577 | 0.69 | TSHR (0.46) | ALDH1A1HSD11B1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699909-B1 | MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS | PRESCIENT NEUROPHARMA INC. (CA) | 2004-03-02 | — | — | US | disclosed |
| US-6699909-B1 | MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS | PRESCIENT NEUROPHARMA INC. (CA) | 2004-03-02 | — | — | US | disclosed |