SCHEMBL7730751

SCHEMBL7730751

CCCCc1ccc(C(F)(F)Oc2ccc(CCc3cc(F)c(C#N)c(F)c3)cc2)c(F)c1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 3/20 0.34
S1PR3 Q99500 2/20 0.34
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PPARG P37231 3/20 0.32
PPARA Q07869 2/20 0.32
ALDH1A1 P00352 2/20 0.32
NPC1 O15118 1/20 0.32
HPGD P15428 1/20 0.32
CASP3 P42574 1/20 0.32
RAB9A P51151 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
SENP8 Q96LD8 1/20 0.32
SENP7 Q9BQF6 1/20 0.32
SENP6 Q9GZR1 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PCSK9 Q8NBP7 1/20 0.32
FFAR1 O14842 1/20 0.31
ALOX5 P09917 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7731392 0.97 TSHR (0.37) S1PR1S1PR3TSHRHSD17B10PPARG
SCHEMBL7729800 0.93 AR (0.33) ALDH1A1HPGDNPSR1FFAR1KDM4E
SCHEMBL7732832 0.91 KIF11 (0.36) S1PR1S1PR3TSHRHSD17B10PPARG
SCHEMBL7732803 0.90 S1PR1 (0.31) S1PR1S1PR3PCSK9
SCHEMBL7733182 0.90 DAO (0.33) TSHRFFAR1DAOTRPV4AR
SCHEMBL7735399 0.89 TSHR (0.34) S1PR1S1PR3TSHRHSD17B10PPARG
SCHEMBL7734975 0.89 TSHR (0.34) S1PR1S1PR3TSHRHSD17B10PPARG
SCHEMBL7731170 0.88 TSHR (0.41) S1PR1TSHRHSD17B10PPARGPPARA
SCHEMBL7729948 0.87 S1PR1 (0.33) S1PR1TSHRHSD17B10PPARGPPARA
SCHEMBL7735124 0.87 S1PR1 (0.37) S1PR1S1PR3PPARGPPARANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed