Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.54 |
| ▸ | CTSS | P25774 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17294365 | 0.94 | CTSK (0.48) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL17294368 | 0.94 | CTSK (0.48) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL16431333 | 0.92 | CTSS (0.46) | CTSKCTSSCTSLCTSB | |
| SCHEMBL26869285 | 0.92 | CTSS (0.49) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL23496889 | 0.90 | CTSS (0.47) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL7333998 | 0.90 | CTSS (0.47) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL15279944 | 0.90 | CTSS (0.47) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL18894022 | 0.90 | CTSS (0.47) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL4283180 | 0.90 | CTSS (0.47) | CTSKCTSSCTSLCTSBAKT1 | |
| SCHEMBL16439602 | 0.89 | BCHE (0.47) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |