Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.47 |
| ▸ | GHSR | Q92847 | 5/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7727252 | 0.91 | KDM4E (0.46) | SIRT2GHSRHDAC8POLB | |
| SCHEMBL7726523 | 0.85 | HDAC8 (0.41) | HDAC8POLB | |
| SCHEMBL7731479 | 0.85 | HDAC8 (0.44) | GHSRHDAC8POLB | |
| SCHEMBL7731725 | 0.84 | HDAC8 (0.44) | HDAC8POLB | |
| SCHEMBL7729236 | 0.81 | HDAC4 (0.41) | HDAC8POLB | |
| SCHEMBL7728192 | 0.79 | POLB (0.47) | HDAC8F10POLB | |
| SCHEMBL7725709 | 0.79 | NPC1 (0.43) | HDAC8POLB | |
| SCHEMBL7722105 | 0.78 | PTPN1 (0.40) | HDAC8POLB | |
| SCHEMBL7727754 | 0.78 | POLB (0.44) | GHSRHDAC8POLB | |
| SCHEMBL7730976 | 0.77 | MCL1 (0.44) | GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |