SCHEMBL7731827

SCHEMBL7731827

CCc1ccc(C(F)(F)Oc2ccc(CCc3ccc(C(F)(F)F)c(F)c3)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.41
FFAR1 O14842 1/20 0.38
KIF11 P52732 1/20 0.37
TRPM8 Q7Z2W7 1/20 0.35
MAOB P27338 2/20 0.35
CYP11B1 P15538 2/20 0.34
CYP11B2 P19099 2/20 0.34
FFAR4 Q5NUL3 1/20 0.34
TAAR1 Q96RJ0 2/20 0.33
GPR84 Q9NQS5 1/20 0.33
TSHR P16473 1/20 0.32
PPARA Q07869 2/20 0.32
PPARD Q03181 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7722922 0.92 DAO (0.41) DAOFFAR1KIF11TRPM8MAOB
SCHEMBL7729630 0.91 KIF11 (0.39) DAOFFAR1KIF11TRPM8CYP11B1
SCHEMBL7730438 0.90 DAO (0.40) DAOFFAR1KIF11TRPM8MAOB
SCHEMBL7733788 0.89 KIF11 (0.40) DAOFFAR1KIF11TRPM8CYP11B1
SCHEMBL7735591 0.89 DAO (0.39) DAOFFAR1KIF11PPARA
SCHEMBL7728951 0.87 KIF11 (0.52) FFAR1KIF11CYP11B1CYP11B2
SCHEMBL7722827 0.86 DAO (0.36) DAOMAOBFFAR4TAAR1GPR84
SCHEMBL7729985 0.86 KIF11 (0.38) DAOFFAR1KIF11TRPM8MAOB
SCHEMBL7730202 0.85 DAO (0.36) DAOMAOBFFAR4TAAR1GPR84
SCHEMBL7729765 0.84 KIF11 (0.38) DAOFFAR1KIF11TRPM8MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed