SCHEMBL7731938

CSc1ncn2c(CO[Si](C)(C)C(C)(C)C)c(C3=C(C(=O)OCc4ccc([N+](=O)[O-])cc4)N4C(=O)[C@H]([C@@H](C)O)[C@H]4C3)sc12

nearest known ligand 0.36

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	L3MBTL1	Q9Y468	1/20	0.36

▸	PLCG1	P19174	1/20	0.33

▸	RAB9A	P51151	1/20	0.33

▸	PAX8	Q06710	1/20	0.33

▸	ELANE	P08246	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7728923	0.91	L3MBTL1 (0.39)	L3MBTL1PLCG1RAB9APAX8ELANE
SCHEMBL7729933	0.88	L3MBTL1 (0.40)	L3MBTL1PLCG1RAB9APAX8ELANE
SCHEMBL7731847	0.88	L3MBTL1 (0.41)	L3MBTL1PLCG1RAB9APAX8ELANE
SCHEMBL7722452	0.86	PLCG1 (0.34)	PLCG1RAB9APAX8ELANE
SCHEMBL6771928	0.85	KDM4E (0.36)	—
SCHEMBL7730782	0.83	L3MBTL1 (0.41)	L3MBTL1PLCG1RAB9APAX8ELANE
SCHEMBL7734230	0.83	L3MBTL1 (0.41)	L3MBTL1PLCG1RAB9APAX8ELANE
SCHEMBL7722624	0.79	L3MBTL1 (0.39)	L3MBTL1PLCG1RAB9APAX8ELANE
SCHEMBL7628844	0.79	PLCG1 (0.34)	PLCG1ELANE
SCHEMBL7722339	0.79	PLCG1 (0.34)	PLCG1ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6458780-B1	IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND	MEIJI SEIKA KAISHA, LTD. (JP)	2002-10-01	—	—	US	disclosed