Serine

SCHEMBL7732130

COC(=O)[C@@H](CCc1ccccc1)NC(=O)OC(C)(C)C.N[C@@H](CO)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	CTSK	P43235	4/20	0.57

▸	CTSS	P25774	4/20	0.57

▸	KLK5	Q9Y337	2/20	0.48

▸	PPARA	Q07869	5/20	0.47

▸	PPARG	P37231	4/20	0.47

▸	ACE	P12821	1/20	0.47

▸	CTSL	P07711	1/20	0.46

▸	CTSB	P07858	1/20	0.46

▸	LNPEP	Q9UIQ6	1/20	0.44

▸	PPARD	Q03181	2/20	0.43

▸	SCN9A	Q15858	1/20	0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Serine SCHEMBL7723282	0.93	CTSK (0.56)	CTSKCTSSPPARAPPARGACE
Serine SCHEMBL7734135	0.92	CTSK (0.55)	CTSKCTSSKLK5PPARAPPARG
SCHEMBL8366306	0.90	CTSK (0.56)	CTSKCTSSKLK5PPARAPPARG
SCHEMBL6344320	0.90	CTSK (0.68)	CTSKCTSSKLK5PPARAPPARG
SCHEMBL7032329	0.90	CTSK (0.68)	CTSKCTSSKLK5PPARAPPARG
SCHEMBL12560624	0.90	CTSK (0.68)	CTSKCTSSKLK5PPARAPPARG
SCHEMBL28584296	0.83	CTSK (0.64)	CTSKCTSSKLK5PPARAPPARG
SCHEMBL25054293	0.83	CTSK (0.61)	CTSKCTSSKLK5PPARAPPARG
SCHEMBL7300194	0.83	CTSK (0.60)	CTSKCTSSKLK5PPARAPPARG
SCHEMBL181775	0.82	CTSK (0.71)	CTSKCTSSPPARAPPARGACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6436980-B1	TRANSPORT PROTEIN SUPPRESSORS; MICROBIOCIDES	ESSENTIAL THERAPEUTICS, INC.	2002-08-20	—	—	US	disclosed
WO-1999037667-A1	EFFLUX PUMP INHIBITORS	MICROCIDE PHARMACEUTICALS, INC. (US)	1999-07-29	—	—	WO	disclosed