Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 4/20 | 0.76 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.55 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.53 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.53 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.53 |
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | FBP1 | P09467 | 1/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734176 | 0.87 | TYMP (0.65) | TYMPADORA1P2RY1SMN1; SMN2P2RY2 | |
| SCHEMBL16554813 | 0.87 | ADORA1 (0.71) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL7067735 | 0.87 | ADORA1 (0.71) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL7067739 | 0.87 | ADORA1 (0.71) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL5270000 | 0.87 | TYMP (1.00) | TYMPADORA1DNPH1SLC29A1STAT6 | |
| SCHEMBL1796310 | 0.87 | TYMP (1.00) | TYMPADORA1DNPH1SLC29A1STAT6 | |
| SCHEMBL22458597 | 0.87 | TYMP (1.00) | TYMPADORA1DNPH1SLC29A1STAT6 | |
| SCHEMBL8207328 | 0.85 | TYMP (0.68) | TYMPADORA1P2RY1SMN1; SMN2P2RY2 | |
| SCHEMBL7197169 | 0.85 | TYMP (0.68) | TYMPADORA1P2RY1SMN1; SMN2P2RY2 | |
| SCHEMBL6560740 | 0.85 | TYMP (0.68) | TYMPADORA1P2RY1SMN1; SMN2P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407076-B1 | ANTIISCHEMIC, ANTILIPOLYTIC, ANTICONVULSANT AND HYPOTENSIVE AGENTS; CARDIOVASCULAR AND NERVOUS SYSTEM DISORDERS; ATHEROSCLEROSIS | SMITHKLINE BEECHAM CORPORATION | 2002-06-18 | — | — | US | disclosed |
| EP-1027363-A2 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999024450-A2 | ADENSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |