Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | STAT1 | P42224 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30561486 | 0.85 | DYRK1A (0.79) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL19807983 | 0.85 | DYRK1A (0.79) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL6058154 | 0.83 | DYRK1A (0.77) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL18472973 | 0.82 | SMN1; SMN2 (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL19807985 | 0.80 | SMN1; SMN2 (0.69) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL6057541 | 0.80 | NPC1 (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL715950 | 0.79 | DYRK1A (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL7734175 | 0.79 | DYRK1A (0.67) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL10170616 | 0.77 | DYRK1A (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2175580 | 0.77 | DYRK1A (1.00) | DYRK1ASMN1; SMN2PIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487498-B1 | HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF | ZHANG XIAOHU (CN) | 2023-09-06 | — | — | EP | disclosed |
| WO-2018017435-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE INC. (KY) | 2018-01-25 | — | — | WO | disclosed |
| US-6407122-B1 | NEUROPROTECTIVE AGENTS, ANTIISCHEMIC, AND HYPERGLYCEMIC AGENTS; HUNTINGTON*S, PARKINSON*S, AND ALZHEIMER*S DISEASE;AMYOTROPHIC LATERAL SCLEROSIS TREATMENT; NERVOUS SYSTEM AND BRAIN DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-18 | — | — | US | disclosed |
| EP-1037890-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999028318-A1 | AMINO-BENZOTHIAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |